P-Cadherin Antikörper (AA 126-336)

Produktnummer ABIN6654133

Der Kaninchen Polyklonal Anti-P-Cadherin-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, P-Cadherin in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für P-Cadherin Antikörper (AA 126-336) (ABIN6654133)

Target: P-Cadherin (CDH3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P-Cadherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-P-Cadherin Antikörper

Bindungsspezifität: AA 126-336

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids Q126-H336 from the human protein were used as the immunogen for the CDH3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CDH3 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant human protein)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the CDH3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu P-Cadherin

Target: P-Cadherin (CDH3)

Andere Bezeichnung: P-Cadherin / CDH3

Hintergrund: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

UniProt: P22223