CASR Antikörper (AA 926-1078)

Produktnummer ABIN6654119

Dieses Anti-CASR-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CASR in WB und FACS. Geeignet für Human.

Kurzübersicht für CASR Antikörper (AA 926-1078) (ABIN6654119)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CASR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: 11E9-

Produktdetails anti-CASR Antikörper

Bindungsspezifität: AA 926-1078

Aufreinigung: Protein G affinity

Immunogen: Human CASR recombinant protein (amino acids Q926-S1078) was used as the immunogen for the CASR antibody.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CASR antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL (human),Flow Cytometry: 1-3 μg/1x10^6 cells (mouse)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the CASR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Andere Bezeichnung: Calcium Sensing Receptor / CASR

Hintergrund: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis