HAVCR1 Antikörper (AA 58-289)

Produktnummer ABIN6654049

Der Kaninchen Polyklonal anti-HAVCR1 Antikörper wird verwendet zum Nachweis von HAVCR1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA (Capture).

Kurzübersicht für HAVCR1 Antikörper (AA 58-289) (ABIN6654049)

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAVCR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA (Capture)

Produktdetails anti-HAVCR1 Antikörper

Bindungsspezifität: AA 58-289

Verwendungszweck: TIM1 Antibody / KIM-1 / HAVCR1

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids Q58-K289 from the human protein were used as the immunogen for the TIM1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TIM1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TIM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu HAVCR1

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Andere Bezeichnung: KIM-1 / TIM-1 / HAVCR1

Substanzklasse: Virus

Hintergrund: TIM1 antibody targets T cell immunoglobulin and mucin domain containing protein 1, commonly referred to as KIM-1 and encoded by the HAVCR1 gene. TIM-1 is a type I transmembrane glycoprotein characterized by an extracellular immunoglobulin V-like domain and a mucin-rich region, followed by a single transmembrane segment and a short cytoplasmic tail. The protein is primarily localized to the plasma membrane and intracellular compartments of epithelial and immune cells, where it functions in injury response and immune regulation. Under basal conditions, TIM-1 expression is low in most tissues but becomes markedly induced in epithelial cells following tissue damage, particularly in the kidney.

Functionally, T cell immunoglobulin and mucin domain containing protein 1 plays a role in cellular responses to injury by acting as a scavenger receptor and modulator of immune signaling. TIM-1 has been shown to bind phosphatidylserine exposed on apoptotic cells, supporting phagocytic clearance and tissue repair processes. In immune cells, TIM-1 can influence activation and cytokine production, linking epithelial stress signals with adaptive immune responses. A TIM1 antibody supports investigations into injury-associated signaling and immune modulation.

Expression of TIM-1 is most prominently associated with proximal tubular epithelial cells in the kidney following injury, reflecting its widespread use as a biomarker for renal damage. Beyond the kidney, inducible expression has been reported in activated T cells and other epithelial tissues under inflammatory or stress-related conditions. This regulated expression pattern underscores a role for TIM-1 in sensing tissue damage and coordinating immune and repair responses rather than maintaining constitutive tissue function.

From a disease-relevance perspective, KIM-1 has been extensively studied in acute kidney injury, chronic kidney disease, and toxicological models of renal damage. Elevated HAVCR1 expression correlates with tubular injury severity and disease progression. TIM-1 has also been explored in inflammatory disorders, transplantation biology, and cancer research, where its roles in immune regulation and epithelial cell behavior may contribute to disease mechanisms. These associations make TIM-1 a valuable target for studies of injury-driven pathology and immune responses.

At the molecular level, the mucin-rich extracellular region of TIM-1 is subject to extensive glycosylation, which can influence receptor stability, ligand interactions, and apparent migration on SDS-PAGE without altering the underlying amino acid sequence. Regulation of TIM-1 function is further influenced by receptor trafficking and cellular context. TIM1 antibody reagents support research applications focused on kidney injury biology, epithelial stress responses, and immune regulatory pathways, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q96D42