Hsc70 Antikörper

Produktnummer ABIN6653942

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch Hsc70 in WB, IHC, IP und ICC. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Huhn und Säugetier.

Kurzübersicht für Hsc70 Antikörper (ABIN6653942)

Target: Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))

Reaktivität: Human, Ratte, Maus, Huhn, Säugetier

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Hsc70 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: 1B5

Produktdetails anti-Hsc70 Antikörper

Spezifität: Reacts with human Hsc70 (Hsp73). Cross-reacts with mouse, rat, rabbit, guinea pig, hamster, monkey, sheep, chicken, bovine, canine and porcine protein.

Aufreinigung: Purified (protein G)

Immunogen: Hsc70 purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB0.1 μg/mL IP5 μg/mL IHC5 μg/mL ICC5 μg/mL

Positive control: HeLa Heat Shocked Cell Lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS pH 7.2, 0.1 mM PMSF in 50 % glycerol.

Konservierungsmittel: PMSF

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot and store at -20°C.

Details zu Hsc70

Target: Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))

Andere Bezeichnung: Hsc70 (Hsp73)

Hintergrund: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes

Heat shock cognate 71 kDa protein Heat shock 70 kDa protein 8 Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1 Gene name: HSPA8, HSC70, HSP73, HSPA10

Gen-ID: 3312

UniProt: P11142