Hsc70 Antikörper

Produktnummer ABIN6653942

Dieser Ratte Monoklonal Antikörper erkennt spezifisch Hsc70 in WB, IHC, IP und ICC. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Huhn und Säugetier.

Kurzübersicht für Hsc70 Antikörper (ABIN6653942)

Target: Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))

Reaktivität: Human, Ratte, Maus, Huhn, Säugetier

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Hsc70 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: 1B5

Produktdetails anti-Hsc70 Antikörper

Spezifität: Reacts with human Hsc70 (Hsp73). Cross-reacts with mouse, rat, rabbit, guinea pig, hamster, monkey, sheep, chicken, bovine, canine and porcine protein.

Aufreinigung: Purified (protein G)

Immunogen: Hsc70 purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB0.1 μg/mL IP5 μg/mL IHC5 μg/mL ICC5 μg/mL

Positive control: HeLa Heat Shocked Cell Lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS pH 7.2, 0.1 mM PMSF in 50 % glycerol.

Konservierungsmittel: PMSF

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot and store at -20°C.

Details zu Hsc70

Target: Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))

Andere Bezeichnung: Hsc70 (Hsp73)

Hintergrund: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes

Heat shock cognate 71 kDa protein Heat shock 70 kDa protein 8 Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1 Gene name: HSPA8, HSC70, HSP73, HSPA10

Gen-ID: 3312

UniProt: P11142