Der Maus Monoklonal anti-Thrombomodulin Antikörper wird verwendet zum Nachweis von Thrombomodulin in Proben von Human und Kaninchen. Er wurde validiert für FACS, IHC (p) und IHC (fro).
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody undiluted at -20 °C.
Target
Thrombomodulin (THBD)
Andere Bezeichnung
CD141 / THBD
Hintergrund
CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.Synonyms: Fetomodulin, THRM, Thrombomodulin