HLA-DQ1/DQ2 Antikörper (AA 131-180)

Produktnummer ABIN6579687

Der Kaninchen Polyklonal anti-HLA-DQ1/DQ2 Antikörper wird verwendet zum Nachweis von HLA-DQ1/DQ2 in Proben von Human. Er wurde validiert für ELISA, WB, IF und IHC.

Kurzübersicht für HLA-DQ1/DQ2 Antikörper (AA 131-180) (ABIN6579687)

Target: HLA-DQ1/DQ2 (MHC Class II HLA-DQ1/DQ2 (HLA-DQ1/DQ2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DQ1/DQ2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-HLA-DQ1/DQ2 Antikörper

Bindungsspezifität: AA 131-180

Verwendungszweck: HLA-DQB1/2 Antibody

Spezifität: HLA-DQB1/2 Polyclonal Antibody detects endogenous levels of HLA-DQB1/2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQB1/HLA-DQB2. AA range:131-180

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu HLA-DQ1/DQ2

Target: HLA-DQ1/DQ2 (MHC Class II HLA-DQ1/DQ2 (HLA-DQ1/DQ2))

Andere Bezeichnung: HLA-DQB1/2

Hintergrund:

Synonyms: HLA-DQB1, HLA-DQB, HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II antigen DQB1, HLA-DQB2, HLA-DXB, HLA class II histocompatibility antigen, DQ beta 2 chainHLA class II histocompatibility antigen, DX beta chain, MHC class II antigen DQB2

Background: major histocompatibility complex, class II, DQ beta 1(HLA-DQB1) Homo sapiens HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro

Gene Name: HLA-DQB1/HLA-DQB2

Protein Name: HLA class II histocompatibility antigen DQ beta 1 chain/HLA class II histocompatibility antigen DQ beta 2 chain

Molekulargewicht: 29 kDa

Gen-ID: 100507714

UniProt: P01920