Nodal Antikörper (AA 294-343)

Produktnummer ABIN6579641

Der Kaninchen Polyklonal anti-Nodal Antikörper wird verwendet zum Nachweis von Nodal in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA, IHC und IF.

Kurzübersicht für Nodal Antikörper (AA 294-343) (ABIN6579641)

Target: Nodal (NODAL) (Nodal Homolog (NODAL))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nodal Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Nodal Antikörper

Bindungsspezifität: AA 294-343

Verwendungszweck: Nodal Antibody

Spezifität: Nodal Polyclonal Antibody detects endogenous levels of Nodal protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human NODAL. AA range:294-343

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Nodal

Target: Nodal (NODAL) (Nodal Homolog (NODAL))

Andere Bezeichnung: NODAL

Hintergrund:

Synonyms: NODAL, Nodal homolog

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016],

Gene Name: NODAL

Protein Name: Nodal homolog

Molekulargewicht: 39 kDa

Gen-ID: 4838

OMIM: 270100

UniProt: Q96S42

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of Endopeptidase Activity