IGF2R Antikörper (AA 2251-2300)

Produktnummer ABIN6579525

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IGF2R in WB, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für IGF2R Antikörper (AA 2251-2300) (ABIN6579525)

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-IGF2R Antikörper

Bindungsspezifität: AA 2251-2300

Verwendungszweck: IGF-IIR Antibody

Spezifität: IGF-IIR Polyclonal Antibody detects endogenous levels of IGF-IIR protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human IGF2R. AA range:2251-2300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu IGF2R

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Andere Bezeichnung: IGF2R

Hintergrund:

Synonyms: IGF2R, MPRI, Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, CD222

Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele, however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],

Gene Name: IGF2R

Protein Name: Cation-independent mannose-6-phosphate receptor

Molekulargewicht: 274 kDa

Gen-ID: 3482

OMIM: 147280

UniProt: P11717