MMP16 Antikörper (C-Term)

Produktnummer ABIN657636

Produktdetails anti-MMP16 Antikörper

Target: MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))

Bindungsspezifität: AA 519-548, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MMP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 519-548 amino acids from the C-terminal region of human MMP16.

Klon: RB33657

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: MMP16 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-MMP16 Antikörper (ABIN657636)

Wu, Ma, Shan, Zhou, Li: "High expression of matrix metalloproteinases 16 is associated with the aggressive malignant behavior and poor survival outcome in colorectal carcinoma." in: Scientific reports, Vol. 7, pp. 46531, (2017) (PubMed).

Shen, Wang, Yu, Zhang, Qin: "MMP16 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma." in: Oncotarget, Vol. 8, Issue 42, pp. 72197-72204, (2017) (PubMed).

Details zu MMP16

Target: MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))

Andere Bezeichnung: MMP16 (MMP16 Produkte)

Hintergrund: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Molekulargewicht: 69521

Gen-ID: 4325

NCBI Accession: NP_005932

UniProt: P51512