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APP Antikörper (AA 333-362)

Dieses Anti-APP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von APP in WB, IF und IHC (p). Geeignet für Human.
Produktnummer ABIN657612

Kurzübersicht für APP Antikörper (AA 333-362) (ABIN657612)

Target

Alle APP Antikörper anzeigen
APP (Amyloid beta (A4) Precursor Protein (APP))

Reaktivität

  • 259
  • 117
  • 112
  • 11
  • 9
  • 8
  • 8
  • 8
  • 8
  • 7
  • 6
  • 5
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 214
  • 86
  • 4
  • 4
  • 3
  • 2
Kaninchen

Klonalität

  • 231
  • 80
  • 1
Polyklonal

Konjugat

  • 175
  • 26
  • 20
  • 18
  • 7
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser APP Antikörper ist unkonjugiert

Applikation

  • 200
  • 151
  • 96
  • 52
  • 52
  • 48
  • 44
  • 41
  • 33
  • 29
  • 15
  • 6
  • 5
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB33592
  • Bindungsspezifität

    • 30
    • 27
    • 24
    • 22
    • 17
    • 17
    • 11
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 333-362

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 amino acids from the Central region of human APP.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    APP Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

    Haltbarkeit

    6 months
  • Target

    APP (Amyloid beta (A4) Precursor Protein (APP))

    Andere Bezeichnung

    APP

    Hintergrund

    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

    Molekulargewicht

    86943

    Gen-ID

    351

    NCBI Accession

    NP_000475, NP_001129488, NP_001129601, NP_001129602, NP_001129603, NP_001191230, NP_001191231, NP_001191232, NP_958816, NP_958817

    UniProt

    P05067

    Pathways

    Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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