NCOR2 Antikörper (AA 994-1005)

Produktnummer ABIN190289

Der Maus Monoklonal Anti-NCOR2-Antikörper wurde für WB, IP und IF/ICC validiert. Er ist geeignet, NCOR2 in Proben von Human zu detektieren.

Kurzübersicht für NCOR2 Antikörper (AA 994-1005) (ABIN190289)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NCOR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC)

Klon: H7

Produktdetails anti-NCOR2 Antikörper

Bindungsspezifität: AA 994-1005

Verwendungszweck: Anti-Smrt Mouse Monoclonal Antibody

Spezifität: This antibody recognizes human SMRT.

Kreuzreaktivität: Human

Immunogen: A KLH-conjugated synthetic peptide derived from human SMRT corresponding to aa 994-1005

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunoblotting and
Immunoprecipitation: use at 1-5 μg/mL.
Positive control: HBL100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Konzentration: Lot specific

Buffer: 10 mM PBS, pH 7.4.

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Details zu NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Andere Bezeichnung: NCOR2 / SMRT

Hintergrund: Nuclear receptor corepressor 2,Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {PubMed:18212045, PubMed:20812024, PubMed:23911289}.,SMRT (Silencing Mediator for Retinoid and Thyroid receptors) is a 168 kD nuclear protein. Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand, there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription.,Nucleus.,N-CoR2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, T3 receptor-associating factor, TRAC, Thyroid-, retinoic-acid-receptor-associated corepressor

UniProt: Q9Y618

Pathways: Notch Signalweg, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha