NSD1 Antikörper

Produktnummer ABIN6572111

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NSD1 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für NSD1 Antikörper (ABIN6572111)

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NSD1 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human NSD1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NSD1

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Andere Bezeichnung: NSD1

Hintergrund:

Synonyms: Nuclear Receptor Binding SET Domain Protein 1,Nuclear Receptor-Binding SET Domain-Containing Protein 1,Androgen Receptor-Associated Protein Of 267 KDa,Androgen Receptor Coactivator 267 KDa Protein,NR-Binding SET Domain-Containing Protein,Lysine N-Methyltransferase 3B,H3-K36-HMTase,H4-K20-HMTase,EC 2.1.1.43.

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Molekulargewicht:

Observed_MW: 297kDa

Calculated_MW: 267kDa/284kDa/296kDa

Gen-ID: 64324

UniProt: Q96L73