Synonyms: C21orf43,CD 322,CD322,CD322 antigen,JAM 2,JAM B,JAM IT/VE JAM,JAM,vascular endothelial,JAM-2,JAM-B,JAM2,JAM2,JAMB,Jcam2,Junction adhesion molecule 2,Junction adhesion molecule B,Junctional adhesion molecule 2,Junctional adhesion molecule B,PRO 245,PRO245,Vascular endothelial junction associated molecule,Vascular endothelial junction-associated molecule,VE JAM,VE-JAM,VEJAM
Background: This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene.