Synonyms: ATP synthase subunit delta, mitochondrial ,ATP synthase subunit delta, mitochondrial,ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit,ATP5D,ATPD,F ATPase delta subunit ,F-ATPase delta subunit,Mitochondrial ATP synthase complex delta subunit precusor ,Mitochondrial ATP synthase delta subunit
Background: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified.