Synonyms: adhesion molecule on glia,AMOG,AT1B2,AT1B2,ATP1B2,ATPase Na+/K+ transporting beta 2 polypeptide,ATPB2,ATPB2S,MGC93648,Na+/K+ -ATPase beta 2 subunit,Na,K ATPase beta 2 polypeptide,RATATPB2S,sodium potassium ATPase subunit beta 2 (non-catalytic),sodium pump subunit beta 2,sodium/potassium dependent ATPase beta 2 subunit,Sodium/potassium dependent ATPase subunit beta 2,sodium/potassium transporting ATPase beta 2 chain,sodium/potassium transporting ATPase subunit beta 2,Sodium/potassium-dependent ATPase subunit beta-2,Sodium/potassium-transporting ATPase subunit beta-2
Background: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene.