Synonyms: dJ221C16.8,H2B histone family, member A,H2B/a,H2B/g,H2B/h,H2B/k,H2B/l,H2B1C,H2BFA,HIST1H2BI,Histone 1, H2bg,Histone cluster 1 H2B family member g,Histone cluster 1, H2bg,Histone H2B type 1-C/E/F/G/I,Histone H2B.1 A,Histone H2B.a,Histone H2B.g,Histone H2B.h,Histone H2B.k,Histone H2B.l
Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.