Synonyms: Beta GR,Beta-glucan receptor,BGR,C type calcium dependent carbohydrate recognition domain lectin superfamily member 12,C type lectin domain family 7 member a,C-type lectin domain family 7 member A,C-type lectin superfamily member 12,CANDF4,CLC7A,CLEC7A,CLEC7A protein,Clecsf12,DC-associated C-type lectin 1,Dectin 1,DECTIN 1 receptor,Dectin-1,Dectin1,Dendritic cell associated C type lectin 1,Dendritic cell-associated C-type lectin 1,Lectin like receptor 1,Putative transmembrane protein dectin 1
Background: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.