Synonyms: cek5,Developmentally regulated EPH related tyrosine kinase,DRT,EK5,ELK related protein tyrosine kinase,Eph receptor B2,EPH tyrosine kinase 3,EPH-like kinase 5,EPHB2,EPHB2,Ephrin type B receptor 2,Ephrin type-B receptor 2,EPHT 3,ERK,ETECK,hEK5,Nuk,Prkm 5,Receptor protein tyrosine kinase HEK 5,Renal carcinoma antigen NY-REN-47,Sek 3,Tyro 5,Tyrosine protein kinase receptor CEK 5,Tyrosine protein kinase receptor EPH 3,Tyrosine protein kinase receptor QEK 5,Tyrosine-protein kinase receptor EPH-3,Tyrosine-protein kinase TYRO5
Background: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants.