Synonyms: CAS,Cellular apoptosis susceptibility protein,Chromosome segregation 1 (yeast homolog) like,Chromosome segregation 1 Like,Chromosome segregation 1 like protein,Chromosome segregation 1-like protein,Chromosome segregation gene CSE1,CSE 1,CSE 1 chromosome segregation 1 like,CSE 1 chromosome segregation 1 like protein,CSE 1L,CSE1,CSE1 chromosome segregation 1 like (yeast),CSE1 chromosome segregation 1 like,CSE1 chromosome segregation 1 like protein,CSE1L,Exp 2,Exp2,Exportin 2,Exportin-2,Exportin2,Importin alpha re exporter,Importin-alpha re-exporter,MGC117283,MGC130036,MGC130037,XPO 2,XPO2,XPO2
Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.