Exportin 2 Antikörper

Produktnummer ABIN6571992

Der Kaninchen Polyklonal Anti-Exportin 2-Antikörper wurde für WB validiert. Er ist geeignet, Exportin 2 in Proben von Human zu detektieren.

Kurzübersicht für Exportin 2 Antikörper (ABIN6571992)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Exportin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Exportin 2 Antikörper

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human CSE1L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Andere Bezeichnung: CSE1L

Hintergrund:

Synonyms: CAS,Cellular apoptosis susceptibility protein,Chromosome segregation 1 (yeast homolog) like,Chromosome segregation 1 Like,Chromosome segregation 1 like protein,Chromosome segregation 1-like protein,Chromosome segregation gene CSE1,CSE 1,CSE 1 chromosome segregation 1 like,CSE 1 chromosome segregation 1 like protein,CSE 1L,CSE1,CSE1 chromosome segregation 1 like (yeast),CSE1 chromosome segregation 1 like,CSE1 chromosome segregation 1 like protein,CSE1L,Exp 2,Exp2,Exportin 2,Exportin-2,Exportin2,Importin alpha re exporter,Importin-alpha re-exporter,MGC117283,MGC130036,MGC130037,XPO 2,XPO2,XPO2

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.

Molekulargewicht:

Observed_MW: 110kDa

Calculated_MW: 22kDa/103kDa/107kDa/110kDa

Gen-ID: 1434

UniProt: P55060

Pathways: Protein targeting to Nucleus