Synonyms: hIST1,Increased sodium tolerance 1,Increased sodium tolerance 1 homolog,IST1 homolog,IST1,KIAA0174,MAPK activating protein PM28,MGC117220,MGC128433,Putative MAPK-activating protein PM28
Background: This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.