HFE2 Antikörper

Produktnummer ABIN5964404

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HFE2 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für HFE2 Antikörper (ABIN5964404)

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HFE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HFE2 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human HFE2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HFE2

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Andere Bezeichnung: HFE2

Hintergrund:

Synonyms: 2310035L15Rik,5230400G09Rik ,AI414844,AI789733,DL M,Haemojuvelin,HEMOCHROMATOSIS,HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN,HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE,HEMOCHROMATOSIS JUVENILE,Hemochromatosis type 2 (juvenile),Hemochromatosis type 2,Hemochromatosis type 2 protein,Hemochromatosis type 2 protein homolog,HEMOCHROMATOSIS, TYPE 2A,HEMOCHROMATOSIS, TYPE 2B,Hemojuvelin,HFE 2,Hfe2,HFE2A,HJV,JH,Juvenile,MGC23953,OTTHUMP00000059680,Repulsive guidance molecule c,RGM C,RGM domain family member C,RGMC

Background: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Molekulargewicht:

Observed_MW: 48kDa

Calculated_MW: 21kDa/33kDa/45kDa

Gen-ID: 148738

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis