Synonyms: HSMT 3,HSMT3,MGC117191,Sentrin 2,Sentrin-2,Sentrin2,Small ubiquitin like modifier 2,Small ubiquitin related modifier 2,Small ubiquitin-related modifier 2,SMT 3B,SMT3 homolog 2,SMT3 suppressor of mif two 3 homolog 2,SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae),SMT3,yeast,homolog 2,Smt3A,SMT3B,SMT3H2,SUMO-2,SUMO-3,SUMO2,SUMO2,Sumo3,Ubiquitin like protein SMT3B,Ubiquitin-like protein SMT3A
Background: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.