PCBP2 Antikörper (Poly(rC) Binding Protein 2)

Details for Product anti-PCBP2 Antibody No. ABIN6569256
Target
Reaktivität
Human, Maus, Ratte
44
22
19
6
5
4
4
4
2
2
2
1
1
1
1
Wirt
Kaninchen
35
9
Klonalität
Polyklonal
Konjugat
Dieser PCBP2 Antikörper ist unkonjugiert
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
34
17
16
12
7
6
4
3
3
1
1
1
1
Optionen
Immunogen Recombinant protein of human PCBP2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PCBP2 (PCBP2 Antibody Abstract)
Hintergrund

Synonyms: Alpha CP2,Alpha-CP2,alphaCP-2,Cbp,CTBP,Heterogeneous nuclear ribonucleoprotein E2,Heterogenous nuclear ribonucleoprotein E2,hnRNP E2,hnRNP-E2,HNRNPE2,Hnrnpx,HNRPE2,Hnrpx,MGC110998,PCBP2,PCBP2,poly(rC) binding protein 2,Poly(rC)-binding protein 2,Putative heterogeneous nuclear ribonucleoprotein X,rCbinding protein 2

Background: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 37kDa

Calculated_MW: 33kDa/34kDa/35kDa/38kDa

Gen-ID 5094
UniProt Q15366
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Poly(rC) Binding Protein 2 (PCBP2) antibody (ABIN6569256) Western blot analysis of extracts of various cell lines, using PCBP2 antibody.
Image no. 2 for anti-Poly(rC) Binding Protein 2 (PCBP2) antibody (ABIN6569256) Immunohistochemistry of paraffin-embedded mouse heart using PCBP2 antibody.
Image no. 3 for anti-Poly(rC) Binding Protein 2 (PCBP2) antibody (ABIN6569256) Immunofluorescence analysis of U2OS cells using PCBP2 antibody.