MBD2 Antikörper

Produktnummer ABIN6569193

Dieses Anti-MBD2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MBD2 in WB und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MBD2 Antikörper (ABIN6569193)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MBD2 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human MBD2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200 - 1:2000 IHC 1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Andere Bezeichnung: MBD2

Hintergrund:

Synonyms: Demethylase,DMTase,MBD 2,Mbd2,MBD2,MBD2a,Methyl CpG binding domain protein 2,Methyl CpG binding protein MBD2,Methyl-CpG-binding domain protein 2,Methyl-CpG-binding protein MBD2,NY CO 41

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 53kDa

Calculated_MW: 31kDa/43kDa

Gen-ID: 8932

UniProt: Q9UBB5

Pathways: Chromatin Binding