Synonyms: 226,2600010P09Rik,AF020312,ATP dependent helicase CHD3,ATP-dependent helicase Chd3,CHD-3,Chd3,CHD3,Chd7,Chromodomain-helicase-DNA-binding protein 3,hZFH,MGC40857,Mi 2 autoantigen 240 kDa protein,Mi 2a,Mi-2 autoantigen 240 kDa protein,Mi2 ALPHA,Mi2-alpha,Prp7,Prp9 1,ZFH,Zinc finger helicase,zinc-finger helicase (Snf2-like)
Background: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.