Importin 5 (IPO5) Antikörper

Details zu Produkt Nr. ABIN6569027
Target
Reaktivität
Human, Maus
28
13
13
1
1
1
1
1
1
1
Wirt
Kaninchen
20
8
Klonalität
Polyklonal
Konjugat
Unkonjugiert
2
2
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
22
9
8
5
5
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human IPO5
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung IPO5 (IPO5 Antibody Abstract)
Hintergrund

Synonyms: DKFZp686O1576,FLJ43041,IMB3,Imp5,Importin 5,Importin beta 3 subunit,Importin subunit beta 3,Importin subunit beta-3,Importin-5,IPO 5,IPO5,IPO5,Karyopherin beta 3,Karyopherin beta-3,KPNB3,MGC2068,Pse1,Ran binding protein 5,Ran GTP binding protein 5,Ran-binding protein 5,RanBP 5,RanBP5

Background: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Molekulargewicht

Observed_MW: 125kDa

Calculated_MW: 116kDa/123kDa/125kDa

Gen-ID 3843
UniProt O00410
Pathways Protein targeting to Nucleus
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Importin 5 (IPO5) antibody (ABIN6569027) Immunofluorescence analysis of U2OS cells using IPO5 antibody.
Image no. 2 for anti-Importin 5 (IPO5) antibody (ABIN6569027) Western blot analysis of extracts of various cell lines, using IPO5 antibody.