Synonyms: C-type lectin domain family 8 member A,CLEC8A,hLOX 1,hLOX-1,Lectin like oxidized LDL receptor 1,Lectin like oxLDL receptor 1,Lectin type oxidized LDL receptor 1,Lectin-like oxidized LDL receptor 1,Lectin-like oxLDL receptor 1,Lectin-type oxidized LDL receptor 1,low density lipoprotein oxidized,receptor 1,LOX-1,LOXIN,Olr1,OLR1,Ox LDL receptor 1,Ox-LDL receptor 1,Oxidised low density lipoprotein (lectin like) receptor 1,Oxidized low density lipoprotein receptor 1,Oxidized low density lipoprotein receptor 1 soluble form,Oxidized low-density lipoprotein receptor 1,SCARE1,Scavenger receptor class E,member 1,SLOX1,soluble form,SR-EI
Background: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.