Insulin-Degrading Enzyme (IDE) Antikörper

Details zu Produkt Nr. ABIN6568815
Target
Reaktivität
Human, Maus
88
35
34
3
3
3
3
3
2
2
1
1
1
Wirt
Kaninchen
69
14
9
Klonalität
Polyklonal
Konjugat
Unkonjugiert
9
6
5
4
3
3
3
3
3
3
3
3
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
64
42
30
14
12
8
6
4
4
2
2
1
1
Optionen
Immunogen Recombinant protein of human IDE
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung IDE (IDE Antibody Abstract)
Hintergrund

Synonyms: Abeta-degrading protease,FLJ35968,Ide,IDE,Insulin protease,Insulin-degrading enzyme,Insulinase,Insulysin,OTTHUMP00000020097

Background: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Molekulargewicht

Observed_MW: 118kDa

Calculated_MW: 54kDa/117kDa

Gen-ID 3416
UniProt P14735
Pathways SARS-CoV-2 Protein Interaktom
Applikations-hinweise WB 1:500 - 1:2000 IF 1:10 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Insulin-Degrading Enzyme (IDE) antibody (ABIN6568815) Western blot analysis of extracts of various cell lines, using IDE antibody.
Image no. 2 for anti-Insulin-Degrading Enzyme (IDE) antibody (ABIN6568815) Immunofluorescence analysis of A549 cells using IDE antibody.