CHRNA7 Antikörper (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal))

Details for Product anti-CHRNA7 Antibody No. ABIN6568785
Target
Reaktivität
Human, Maus, Ratte
73
30
25
6
5
4
4
3
3
3
3
2
Wirt
Kaninchen
54
14
8
Klonalität
Polyklonal
Konjugat
Dieser CHRNA7 Antikörper ist unkonjugiert
5
5
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
50
34
13
7
6
5
3
2
2
1
1
Optionen
Immunogen Recombinant protein of human CHRNA7
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung CHRNA7 (CHRNA7 Antibody Abstract)
Hintergrund

Synonyms: 7nAChR,a7 nicotinic acetylcholine receptor,acetylcholine receptor,neuronal nicotinic,alpha-7 subunit,ACHA7,AChR,Acra7,alpha 7 neuronal nicotinic acetylcholine receptor,alpha-7 nicotinic cholinergic receptor subunit,alpha7,cholinergic receptor,neuronal nicotinic,alpha polypeptide 7,cholinergic receptor,nicotinic,alpha 7 (neuronal),cholinergic receptor,nicotinic,alpha 7,cholinergic receptor,nicotinic,alpha polypeptide 7,CHRNA7,CHRNA7-2,NACHRA7,neuronal acetylcholine receptor protein,alpha-7 chain,Neuronal acetylcholine receptor subunit alpha-7

Background: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Molekulargewicht

Observed_MW: 53kDa

Calculated_MW: 11kDa/56kDa/59kDa

Gen-ID 1139
UniProt P36544
Pathways Synaptic Membrane
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) antibody (ABIN6568785) Western blot analysis of extracts of various cell lines, using CHRNA7 antibody.
Image no. 2 for anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) antibody (ABIN6568785) Immunohistochemistry of paraffin-embedded rat brain using CHRNA7 antibody.