Synonyms: 9430025M21Rik,Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein,Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein,C730009O10Rik,Lamellipodin,PREL-2,Proline-rich EVH1 ligand 2,Protein RMO1,RAPH1,RAPH1,Ras-associated and pleckstrin homology domains-containing protein 1
Background: This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants.