Synonyms: ATPase Na+/K+ Transporting Subunit Alpha 4,Sodium Pump Subunit Alpha-4,ATPase Na+/K+ Transporting, Alpha Polypeptide-Like 2,Sodium/Potassium-Transporting ATPase Subunit Alpha-4,Sodium-Potassium ATPase Catalytic Subunit Alpha-4,ATPase Na+/K+ Transporting, Alpha 4 Polypeptide,Na(+)/K(+) ATPase Alpha-4 Subunit,EC 220.127.116.11,ATP1AL2,Sodium/Potassium-Transporting ATPase Alpha-4 Chain,Na+/K+ ATPase Alpha-D Polypeptide,Na,K-ATPase Subunit Alpha-C,Na+/K+ ATPase 4,Sodium Pump 4,EC 3.6.3,ATP1A1
Background: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.