Synonyms: 72 kDa ICln binding protein,72 kDa ICln-binding protein,ANM5,Histone synthetic lethal 7,S. cerevisiae,homolog of,Histone-arginine N-methyltransferase PRMT5,HMT1 hnRNP methyltransferase like 5,HOMOLOG OF,SKB1,HRMT1L5,IBP72,Jak-binding protein 1,JBP 1,JBP1,PRMT 5,PRMT5,Protein arginine methyltransferase 5,Protein arginine N methyltransferase 5,Protein arginine N methyltransferase 5 N terminally processed,Protein arginine N-methyltransferase 5,S. POMBE,S. POMBE HOMOLOG OF,SKB1,SHK1 KINASE BINDING PROTEIN 1,Shk1 kinase binding protein 1 homolog,Shk1 kinase-binding protein 1 homolog,Shk1 kinase/binding protein 1,S. pombe,homolog of,SKB 1,SKB1,SKB1 homolog,SKB1: SKB1 homolog (S. pombe),SKB1Hs
Background: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms.