EBP Antikörper

Produktnummer ABIN6568497

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EBP in WB. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für EBP Antikörper (ABIN6568497)

Target: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EBP Antikörper

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human EBP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu EBP

Target: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Andere Bezeichnung: EBP

Hintergrund:

Synonyms: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,CDPX2 ,CHO2,Cholestenol Delta-isomerase,CPX,CPXD,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,ebp,EBP,Emopamil-binding protein,Msi

Background: The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).

Molekulargewicht:

Observed_MW: 26kDa

Calculated_MW: 26kDa

Gen-ID: 10682

UniProt: Q15125