Synonyms: 1,4 cineole 2 exo monooxygenase,11B1,CP2B6,CPB 6,CPB6,CYP 2B6,CYP IIB6,CYP2B,CYP2B6,CYP2B7,CYP2B7P,CYPIIB6,Cytochrome P450 2B6,Cytochrome P450 family 2 subfamily B,Cytochrome P450 family 2 subfamily B polypeptide 6,Cytochrome P450 IIB1,Cytochrome P450 phenobarbital inducible,Cytochrome P450 subfamily IIB (phenobarbital inducible),Cytochrome P450 subfamily IIB (phenobarbital inducible) polypeptide 6,Cytochrome P450 subfamily IIB polypeptide 6,EFVM,IIB1,P450,P450 IIB1,P450IIB1
Background: This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.