Coagulation Factor X Antikörper (F10)

Details for Product anti-F10 Antibody No. ABIN6568380
Target
Reaktivität
Human, Maus
99
50
34
9
3
2
2
2
1
1
1
Wirt
Kaninchen
71
21
14
12
9
Klonalität
Polyklonal
Konjugat
Dieser Coagulation Factor X Antikörper ist unkonjugiert
15
11
10
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
73
55
18
17
14
13
13
12
8
8
6
5
5
4
2
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human F10
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung F10 (F10 Antibody Abstract)
Hintergrund

Synonyms: Activated factor Xa heavy chain,Coagulation factor X,F10,FA10,factor Xa,FX,FXA,Prothrombinase,Stuart factor,Stuart Prower factor,Stuart-Prower factor

Background: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds, the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Molekulargewicht

Observed_MW: 75kDa

Calculated_MW: 54kDa

Gen-ID 2159
UniProt P00742
Applikations-hinweise WB 1:500 - 1:2000 IF 1:10 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Coagulation Factor X (F10) antibody (ABIN6568380) Western blot analysis of extracts of various cell lines, using F10 antibody.
Image no. 2 for anti-Coagulation Factor X (F10) antibody (ABIN6568380) Immunofluorescence analysis of A549 cells using F10 antibody.