Coagulation Factor X Antikörper

Produktnummer ABIN6568380

Dieses Anti-Coagulation Factor X-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Coagulation Factor X in IF. Geeignet für Human und Maus.

Kurzübersicht für Coagulation Factor X Antikörper (ABIN6568380)

Target: Coagulation Factor X (F10)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Coagulation Factor X Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktdetails anti-Coagulation Factor X Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human F10 (NP_000495.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Coagulation Factor X

Target: Coagulation Factor X (F10)

Andere Bezeichnung: F10

Hintergrund: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds, the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Molekulargewicht:

Observed_MW: 75kDa

Calculated_MW: 54kDa

Gen-ID: 2159

UniProt: P00742