PMS2 Antikörper (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae))

Details for Product anti-PMS2 Antibody No. ABIN6568121
Target
Reaktivität
Human
78
13
10
2
2
2
1
1
1
1
1
1
1
1
1
Wirt
Kaninchen
55
22
1
Klonalität
Polyklonal
Konjugat
Dieser PMS2 Antikörper ist unkonjugiert
4
2
2
2
2
2
2
2
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
52
34
23
16
12
7
6
3
3
3
1
1
Optionen
Immunogen Recombinant protein of human PMS2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PMS2 (PMS2 Antibody Abstract)
Hintergrund

Synonyms: DNA mismatch repair gene homologue,DNA mismatch repair protein PMS2,H_DJ0042M02.9,HNPCC4,Mismatch repair endonuclease PMS2,Mismatch repair gene PMSL2,MLH4,PMS 2,PMS1 homolog 2 mismatch repair system,PMS1 protein homolog 2,PMS2,PMS2 postmeiotic segregation increased 2,PMS2 postmeiotic segregation increased 2 (S. cerevisiae),PMS2,PMS2CL,PMSL2,Postmeiotic segregation increased,S. cerevisiae,2

Background: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and Turcot syndrome.

Molekulargewicht

Observed_MW: Refer to Figures

Calculated_MW: 20kDa/51kDa/62kDa/95kDa

Gen-ID 5395
UniProt P54278
Pathways DNA Reparatur, Production of Molecular Mediator of Immune Response
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:20 - 1:50
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) antibody (ABIN6568121) Western blot analysis of extracts of various cell lines, using PMS2 antibody.
Image no. 2 for anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) antibody (ABIN6568121) Immunofluorescence analysis of U2OS cells using PMS2 antibody.
Image no. 3 for anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) antibody (ABIN6568121) Immunoprecipitation analysis of 150ug extracts of Jurkat cells using 3ug PMS2 antibody.