Synonyms: Acute lymphoblastic leukemia cells antigen CD38,ADP ribosyl cyclase 1,ADP ribosyl cyclase,ADP ribosyl cyclase/cyclic ADP-ribose hydrolase,ADP-ribosyl cyclase 1,ADPRC 1,ADPRC1,cADPr hydrolase 1,CD 38,CD38,CD38 antigen (p45),CD38 antigen,CD38 Molecule,Cd38-rs1,CD38,CD38H,Cyclic ADP ribose hydrolase,Cyclic ADP ribose hydrolase 1,Cyclic ADP-ribose hydrolase 1,EC 22.214.171.124,Ecto nicotinamide adenine dinucleotide glycohydrolase,I-19,I19 (mouse),Lymphocyte differentiation antigen CD38,NAD(+) nucleosidase,NIM-R5 antigen,NIMR5 antigen (mouse),OTTHUMP00000158633,OTTHUMP00000217743,p45,T10
Background: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.