UGT1A1 Antikörper (UDP Glucuronosyltransferase 1 Family, Polypeptide A1)

Details for Product anti-UGT1A1 Antibody No. ABIN6568068
Target
Reaktivität
Human, Maus, Ratte
53
16
15
2
1
1
1
1
Wirt
Kaninchen
51
3
1
Klonalität
Polyklonal
Konjugat
Dieser UGT1A1 Antikörper ist unkonjugiert
5
4
3
3
3
2
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
41
27
23
21
13
6
5
4
2
2
2
Optionen
Immunogen Recombinant protein of human UGT1A1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung UGT1A1 (UGT1A1 Antibody Abstract)
Hintergrund

Synonyms: BILIQTL1,Bilirubin specific UDPGT isozyme 1 ,bilirubin UDP glucuronosyltransferase 1 1 ,bilirubin UDP glucuronosyltransferase isozyme 1 ,Bilirubin-specific UDPGT isozyme 1,EC 2.4.1.17,GNT1,HUG BR1,HUG-BR1,HUGBR1,PHENOL/BILIRUBIN UDP GLUCURONOSYLTRANSFERASE,UD11,UDP glucuronosyltransferase 1 1 [Precursor],UDP glucuronosyltransferase 1 family polypeptide A1 ,UDP glucuronosyltransferase 1A1,UDP GLYCOSYLTRANSFERASE 1,UDP-glucuronosyltransferase 1-1,UDP-glucuronosyltransferase 1-A,UDP-glucuronosyltransferase 1A1,UDPGT ,UDPGT 1-1,UGT 1A,UGT-1A,UGT1 ,UGT1 01,UGT1*1,UGT1-01,UGT1.1,UGT1A,Ugt1a1,URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE, BILIRUBIN/PHENOL,URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1,URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1

Background: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Molekulargewicht

Observed_MW: 75kDa

Calculated_MW: 49kDa/59kDa

Gen-ID 54658
UniProt P22309
Pathways Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) antibody (ABIN6568068) Western blot analysis of extracts of various cell lines, using UGT1A1 antibody.