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UGT1A1 Antikörper

Der Kaninchen Polyklonal Anti-UGT1A1-Antikörper wurde für WB validiert. Er ist geeignet, UGT1A1 in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN6568068

Kurzübersicht für UGT1A1 Antikörper (ABIN6568068)

Target

Alle UGT1A1 Antikörper anzeigen
UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Reaktivität

  • 45
  • 16
  • 15
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 43
  • 4
  • 1
Kaninchen

Klonalität

  • 44
  • 4
Polyklonal

Konjugat

  • 27
  • 4
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser UGT1A1 Antikörper ist unkonjugiert

Applikation

  • 30
  • 23
  • 18
  • 14
  • 13
  • 7
  • 5
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB)
  • Aufreinigung

    Affinity purification

    Immunogen

    Recombinant protein of human UGT1A1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500 - 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

    Andere Bezeichnung

    UGT1A1

    Hintergrund

    Synonyms: BILIQTL1,Bilirubin specific UDPGT isozyme 1 ,bilirubin UDP glucuronosyltransferase 1 1 ,bilirubin UDP glucuronosyltransferase isozyme 1 ,Bilirubin-specific UDPGT isozyme 1,EC 2.4.1.17,GNT1,HUG BR1,HUG-BR1,HUGBR1,PHENOL/BILIRUBIN UDP GLUCURONOSYLTRANSFERASE,UD11,UDP glucuronosyltransferase 1 1 [Precursor],UDP glucuronosyltransferase 1 family polypeptide A1 ,UDP glucuronosyltransferase 1A1,UDP GLYCOSYLTRANSFERASE 1,UDP-glucuronosyltransferase 1-1,UDP-glucuronosyltransferase 1-A,UDP-glucuronosyltransferase 1A1,UDPGT ,UDPGT 1-1,UGT 1A,UGT-1A,UGT1 ,UGT1 01,UGT1*1,UGT1-01,UGT1.1,UGT1A,Ugt1a1,URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE, BILIRUBIN/PHENOL,URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1,URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1

    Background: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

    Molekulargewicht

    Observed_MW: 75kDa

    Calculated_MW: 49kDa/59kDa

    Gen-ID

    54658

    UniProt

    P22309

    Pathways

    Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
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