Synonyms: 52 kDa ribonucleoprotein autoantigen Ro/SS-A,52 kDa Ro protein,52kD Ro/SSA autoantigen,Autoantigen Ro/SSA,52-KD,E3 ubiquitin-protein ligase TRIM21,RING finger protein 81,RNF81,Ro 52,Ro(SS-A),Ro52,RO52,Sicca syndrome antigen A,Sjoegren syndrome type A antigen,Sjogren syndrome antigen A1,Sjogren syndrome type A antigen,SS-A,SSA,SSA1: Sjogren syndrome antigen A1 (52 kDa ribonucleoprotein autoantigen SS-A/Ro),TRIM21,Tripartite motif protein TRIM21,Tripartite motif-containing 21,Tripartite motif-containing protein 21
Background: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.