Synonyms: Arginine rich mutated in early stage tumors,Arginine rich protein,Arginine-rich protein,ARMET,ARMET protein,ARP,Manf,MANF,Mesencephalic astrocyte derived neurotrophic factor,Mesencephalic astrocyte-derived neurotrophic factor,MGC142148,MGC142150,Protein ARMET
Background: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.