MANF Antikörper (Mesencephalic Astrocyte-Derived Neurotrophic Factor)

Details for Product anti-MANF Antibody No. ABIN6567918
Target
Reaktivität
Human
69
27
25
2
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
55
9
7
Klonalität
Polyklonal
Konjugat
Dieser MANF Antikörper ist unkonjugiert
5
4
3
3
3
3
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
60
47
18
7
6
5
4
3
2
1
1
1
Optionen
Immunogen Recombinant protein of human MANF
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MANF (MANF Antibody Abstract)
Hintergrund

Synonyms: Arginine rich mutated in early stage tumors,Arginine rich protein,Arginine-rich protein,ARMET,ARMET protein,ARP,Manf,MANF,Mesencephalic astrocyte derived neurotrophic factor,Mesencephalic astrocyte-derived neurotrophic factor,MGC142148,MGC142150,Protein ARMET

Background: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Molekulargewicht

Observed_MW: 16kDa

Calculated_MW: 20kDa

Gen-ID 7873
UniProt P55145
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibody (ABIN6567918) Immunohistochemistry of paraffin-embedded human colon carcinoma using MANF antibody.
Image no. 2 for anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibody (ABIN6567918) Immunohistochemistry of paraffin-embedded human liver using MANF antibody.
Image no. 3 for anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibody (ABIN6567918) Western blot analysis of extracts of various cell lines, using MANF Antibody.