ETV1 Antikörper (Ets Variant 1)

Details for Product anti-ETV1 Antibody No. ABIN6567870
Target
Reaktivität
Human, Maus, Ratte
51
33
23
6
5
4
4
3
2
2
2
2
2
1
Wirt
Kaninchen
39
7
5
Klonalität
Polyklonal
Konjugat
Dieser ETV1 Antikörper ist unkonjugiert
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC)
25
22
13
8
5
3
2
1
1
1
Optionen
Immunogen Recombinant protein of human ETV1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung ETV1 (ETV1 Antibody Abstract)
Hintergrund

Synonyms: DKFZp781L0674,ER81,ER81 protein,ER81,mouse,homolog of,ETS translocation variant 1,ets variant gene 1,Ets-related protein 81,Etsrp81,ETV 1,ETV1,ETV1,MGC104699,MGC120533,MGC120534

Background: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht

Calculated_MW: 43kDa/48kDa/50kDa/52kDa/53kDa/55kDa

Gen-ID 2115
UniProt P50549
Applikations-hinweise IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Ets Variant 1 (ETV1) antibody (ABIN6567870) Immunohistochemistry of paraffin-embedded rat pancreas using ETV1 antibody.
Image no. 2 for anti-Ets Variant 1 (ETV1) antibody (ABIN6567870) Immunohistochemistry of paraffin-embedded human breast cancer using ETV1 antibody.
Image no. 3 for anti-Ets Variant 1 (ETV1) antibody (ABIN6567870) Immunofluorescence analysis of A549 cells using ETV1 antibody.