ETV1 Antikörper

Produktnummer ABIN6567870

Dieses Anti-ETV1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ETV1 in IHC und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ETV1 Antikörper (ABIN6567870)

Target: ETV1 (Ets Variant 1 (ETV1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ETV1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-ETV1 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human ETV1 (NP_004947.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200 IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ETV1

Target: ETV1 (Ets Variant 1 (ETV1))

Andere Bezeichnung: ETV1

Hintergrund: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht:

Calculated_MW: 43kDa/48kDa/50kDa/52kDa/53kDa/55kDa

Gen-ID: 2115

UniProt: P50549