Integrin alpha-8 / ITGA8 Antikörper

Details zu Produkt Nr. ABIN6567752
Target
Reaktivität
Human, Maus, Ratte
40
8
3
2
2
1
1
1
1
1
1
Wirt
Kaninchen
34
6
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
3
3
2
2
2
1
1
1
1
1
1
Applikation
Western Blotting (WB)
36
22
19
7
4
3
2
1
Optionen
Immunogen Recombinant Protein of human ITGA8
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung ITGA8
Hintergrund

Synonyms: Integrin alpha 8,Integrin alpha-8 heavy chain,Integrin alpha-8 light chain,ITA8,ITGA 8,ITGA8

Background: Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht

Observed_MW: 117kDa

Calculated_MW: 117kDa

Gen-ID 8516
UniProt P53708
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Integrin alpha-8 / ITGA8 antibody (ABIN6567752) Western blot analysis of extracts of various cell lines, using ITGA8 antibody.