Synonyms: Protein RUFY3,rap2 interacting protein x,Rap2 interacting protein x isoform 2,Rap2-interacting protein x,RIPx,Rpipx,Rufy3,RUFY3,RUN and FYVE domain containing 3,Singar,Singar1,Single axon regulated protein,single axon related 1,Single axon-regulated protein
Background: This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants.