Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Antikörper

Details zu Produkt Nr. ABIN6567658
Target
Reaktivität
Human, Maus
40
Wirt
Kaninchen
25
15
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
5
2
2
2
2
1
Applikation
Western Blotting (WB)
34
25
20
15
6
4
4
3
2
2
2
Optionen
Immunogen Recombinant protein of human KIR2DL4
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung KIR2DL4 (KIR2DL4 Antibody Abstract)
Hintergrund

Synonyms: CD_antigen=CD158d,CD158 antigen like family member D,CD158 antigen-like family member D,CD158d,G9P,KI2L4,Killer cell immunoglobulin like receptor 2DL4,Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4,Killer cell immunoglobulin-like receptor 2DL4,Killer cell inhibitory receptor 103AS,Killer Ig receptor,KIR 103AS,KIR-103AS,KIR103,KIR103AS,KIR2DL4,MHC class I NK cell receptor KIR103AS,Natural killer cell inhibitory receptor,NK cell receptor,NK cell receptor, natural killer cell inhibitory receptor,OTTHUMP00000068612,OTTHUMP00000068614,OTTHUMP00000068615

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly.

Molekulargewicht

Observed_MW: 39kDa, 41kDa

Calculated_MW: 24kDa/33kDa/35kDa/37kDa/39kDa/41kDa

Gen-ID 3805
UniProt Q99706
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) antibody (ABIN6567658) Western blot analysis of extracts of various cell lines, using KIR2DL4 antibody.