CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A) Antikörper

Details zu Produkt Nr. ABIN6567586
Target
Reaktivität
Human, Maus, Ratte
24
15
9
6
5
4
3
3
2
2
1
1
Wirt
Kaninchen
23
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
18
7
5
1
Optionen
Immunogen Recombinant protein of human CHRFAM7A
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung CHRFAM7A (CHRFAM7A Antibody Abstract)
Hintergrund

Synonyms: Alpha 7 neuronal nicotinic acetylcholine receptor FAM7A hybrid,CHRNA7 (cholinergic receptor nicotinic alpha 7 exons 5 10) and FAM7A (family with sequence similarity 7A exons A E) fusion,CHRNA7,CHRNA7 DR1,CHRNA7 FAM7A fusion,CHRNA7 FAM7A fusion protein,D 10,D10,MGC120482,MGC120483

Background: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

Molekulargewicht

Observed_MW: 50kDa

Calculated_MW: 46kDa

Gen-ID 89832
UniProt Q494W8
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A) antibody (ABIN6567586) Western blot analysis of extracts of various cell lines, using CHRFAM7A antibody.