Synonyms: Maxp 1,MAXP1,MGC10823,MGC17344,New ras effector 1,NORE 1,NORE1A,NORE1B,Novel Ras effector 1,RAP1 Binding Protein,RAPL,Ras association (RalGDS/AF 6) domain family 5,Ras association (RalGDS/AF 6) domain family member 5,Ras association domain containing family protein 5,Ras association domain-containing protein 5,Ras effector like protein,RASF5,RASSF 3,RASSF 5,RASSF3,RASSF5,Regulator for cell adhesion and polarization enriched in lymphoid tissue ,Regulator for cell adhesion and polarization enriched in lymphoid tissues,Tumor suppressor RASSF3
Background: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.